题目：Network dynamics during healthy and disease development
时间：2014.11.19，下午：14:00 - 15:30
地点：新科技楼1012会议室
报告人简介：
Tan Kai，博士， University of Iowa副教授。华盛顿大学圣路易斯分校（Washington University in Saint Louis）系统生物学博士，美国加州大学圣地亚哥分校(University of California at San Diego)博士后，师从系统生物学创始人Trey Ideker教授。担任《BMC Genomics》副主编，十多个顶级国际期刊的特约审稿人，如《Proc. Natl. Acad. Sci.》、《Nature Biotech》、《Nucleic Acids Research》、《Genome Research》、《Genome Biology》等。担任国际著名计算生物会议的委员会委员，如ICDM、RECOMB、ISMB、BIBM等。同时担任美国NIH、英国BBSRC、奥地利ASF基金评审委员会评委。
Tan教授在机器学习与数据挖掘、计算生物信息学进行了长期的研究，在该领域的研究中获得多项美国国家卫生部重大项目的资助，包括NIH/NHLBI、NIH/NHGRI、NIH/NIDA等。并在该领域的国际著名期刊《Cell》、《Nature Genetics》、《Nature Immunology》、《Blood》、《PNAS》、《Nucleic Acids Research》、《Genome Research》、《Genome Biology》、《Bioinformatics》等发表论文，代表性研究成果如下：
[1]
Tan K, Moreno-Hagelsieb G, Collado-Vides J, et al. 2001. A comparative genomics approach to prediction of new members of regulons. Genome Research. 11: 566-584. 【IF=14.4,JCR=1】
[2]
Tan K, McCue LA, and Stormo GD. 2005. Making connections between novel transcription factors and their DNA motifs. Genome Research. 15: 312-320. 【IF=14.4,JCR=1】
[3]
Tan K, Shlomi T, Feizi, H, Ideker T, and Sharan R. 2007. Transcriptional regulationof protein complexes within and across species. Proc. Natl. Acad. Sci. 104(4): 1283-1288. 【IF=9.7,JCR=1】
[4]
Tan K*, Feizi H, Luo C, Fan S, Ravasi T, and Ideker T. 2008. A systems approach to delineate functions of paralogous transcription factors: Role of the Yap family in the DNA damage response. Proc. Natl. Acad. Sci. 105(8): 2934-2939. (Highlighted by Faculty of 1000)
[5]
The FANTOM consortium & Riken Omics Science Center. 2009. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics. 41(5): 553-562. 【IF=35.2,JCR=1】
[6]
Kuo D, Licon K, Bandyopadhyay S, Chuang R, Luo C, Catalana J, Ravasi T, Tan K*, Ideker T*. 2010. Co-evolution within a transcriptional network by compensatory trans and cismutations. Genome Research. 20(12):1672-1678 【IF=14.4，JCR=1】
[7]
Ravasi T, Cannistraci CV, Katayama S, Bajic VB, Tan K &FANTOM consortium & Riken Omics Science Center. 2010. An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 140:744-752. 【IF=34.3，JCR=1】
[8]
Firpi HA, Ucar D, and Tan K*. 2010. Discover regulatory DNA elements using chromatin signatures and artificial neural network. Bioinformatics. 26:1579-86. 【IF=6.9,JCR=1】
[9]
Kuo D†, Tan K†, Zinman G, Ravasi T, Bar-Joseph Z, Ideker T. 2010. Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Genome Biology.11:R77. 【IF=10.3,JCR=1】
